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Increased ROS production, mitochondrial dysfunction, lipid peroxidation, and a compromised antioxidant defense system are the main causes of oxidative stress brought on by OLZ
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When SAM is reduced as occurs downstream of MTHFR-impaired methionine regeneration DNA methyltransferase activity is substrate-limited, producing a pattern of progressive CpG methylation loss at sites that require continuous active maintenance
The nonclassical pyroptosis pathway is mediated by caspase-4/5/11
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